It depends so much on amp and guitar.
I can give you my current setting for practice.
I play on a Fender Stratocaster and a Yamaha THR10ii.
I have the Fender on neck position 4.
I have gain up enough so it's there, bass dialed back, middle a bit higher and treble a bit higher than the middle. With a slight of reverb.
But how does that help if your gear is different? :)
"You find a lot of people these days who cannot stand to be alone. You could lock me up in solitary for weeks on end, and I'd keep myself amused."