I bought a Tele Player Edition around two years ago from a store that also sells 'as it arrived from the manufacturer' online.

Main issues were a couple of raised frets, the intonation was out, and both pickups lower than optimum level. The neck relief was also a little too straight for my liking.

Some truss rod adjustment and 24 hours to settle later, I spent around one hour giving it a proper setup. Since then it's played like a dream (although I am considering lowering the action a little, but that's purely personal preference).

The Player does have 6 adjustable saddles, so intonation for each string is just a case of setting each one.

For anyone who can't do a setup, there are plenty of stores with techs who can.